Global analysis of SUMO chain function reveals multiple roles in chromatin regulation

In this screen two mutant yeast strains unable to synthesize SUMO chains (pro-smt3allR and smt3allR), were crossed with 384 yeast strains expressing GFP-tagged proteins (Huh et al., 2003) previously linked to the DNA damage response (Tkach et al., 2012). 144 GFP-tagged proteins displayed a change in localization and/or intensity when expressed in the smt3allR mutant grown in rich medium.

Srikumar T, Lewicki MC, Costanzo M, Tkach JM, van Bakel H, Tsui K, Johnson ES, Brown GW, Andrews BJ, Boone C, Giaever G, Nislow C, Raught B

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