A new method for reliably detecting single fluorescent puncta in structured backgrounds
We took 5400 field of views from three Parkinson's disease (PD) cases in the anterior cingulate gyrus for microglia and neuron markers respectively, covering dimensions of 4mm x 4mm x 13m per patient. Cells were stained in 488nm channel while alpha-synuclein protein was labelled in 561nm channel. The colocalization study was performed based on the locations of detected cells and alpha-synucleins.
Fu B, Brock E, Andrews R, Breiter J, Tian R, Toomey C, Lachica J, Lashley T, Ryten M, Wood N, Vendruscolo M, Gandhi S, Weiss LE, Beckwith JS, Lee SF
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idr0155-fu-alphasynuclein/experimentA ()
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Sample Type: tissue
Organism: Homo sapiens
Study Type: protein localization
Imaging Method: spinning disk confocal microscopy
Copyright: Fu at al
Data Publisher: University of Dundee
Annotation File: idr0155-experimentA-annotation.csv
