Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies

To systematically assess whether coculture studies provide superior biological insights for drug screening, we performed a large-scale study comparing compound efficacy in leukemia monoculture and leukemia-stroma coculture. We used the well-established bone-marrow derived stroma cell line HS-5 and an imaging-based platform to investigate not only drug effects in mono- and leukemia-stroma coculture but also to capture cellular changes due to the stromal environment and drug treatments.

Herbst SA, Kim V, Roider T, Schitter EC, Bruch PM, Liebers N, Kolb C, Knoll M, Lu J, Dreger P, Müller-Tidow C, Zenz T, Huber W, Dietrich S

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