Live imaging of remyelination in the adult mouse corpus callosum

We genetically targeted OPCs using mice expressing a tamoxifen (Tam)-inducible Cre recombinase under the control of the endogenous Achaete-scute homolog 1 (Ascl1) promoter crossed with a tdTomato reporter mouse line (Ascl1-tdTomato mice). To induce focal demyelination in the CC, mice were injected with LPC in the posterior CC. Mice were implanted with a transcortical window allowing for optical access using 2-photon microscopy. Tamoxifen (TAM) was injected 2 and 3 days after LPC injection to induce sparse labeling of Ascl1-targeted OPCs. Labeled OPC clones were imaged every day up to two months.

Bottes S, Jessberger S

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