Mapping the perturbome network of cellular perturbations

We used high-content screening and image analysis to measure the effect of 267 well described drugs as well as all possible 35,511 pairwise combinations. We applied a novel mathematical framework that uses the complex high-dimensional morphological space of drug induced phenotypes, to detect 1832 interactions between two drug perturbations. In contrast to previous methodologies our novel framework not only detects the type of interaction (e.g. positive/negative) but also its directionality. Subsequent analysis of the chemical and biological features of the drug compounds reveals distinct molecular fingerprints for each interaction type.

Caldera M, Müller F, Kaltenbrunner I, Licciardello MP, Lardeau C, Kubicek S, Menche J

Browse Data in IDR

idr0069-caldera-perturbome/screenA ()

BioFile Finder

BioFile Finder is a tool for filtering, sorting and grouping tabular data. Each table below is loaded from IDR as a Parquet file, with each row representing an image. Images can be selected in BioFile Finder and the "Download" link will open them in the IDR viewer.

NB: large tables may take some time to load in BioFile Finder.

screenA ( , parquet: -)

Download

To download original image files in your browser, you can access original data.

Download as JSON.

For more download options, including bulk download using Globus or FTP clients, see the IDR Data download page.