High-Content Phenotypic Profiling of Drug Response Signatures across Distinct Cancer Cells

The images are of MCF-7 breast cancer cells treated for 24 h with a collection of 113 small molecules at eight concentrations. The cells were fixed, labeled for DNA, F-actin, and B-tubulin, and imaged by fluorescent microscopy as described [Caie et al. Molecular Cancer Therapeutics, 2010]. Note: The images in idr0035/screenA were generated by Caie et al, 2010 and are from MCF7 wild-type cells only. They were obtained from the Broad BioImage Benchmark Collection image set BBBC021v1 (https://data.broadinstitute.org/bbbc/BBBC021/) submitted by Ljosa et al, 2013. The Mechanism of Action ground truth data comes from Ljosa et al, 2013.

Caie PD, Walls RE, Ingleston-Orme A, Daya S, Houslay T, Eagle R, Roberts ME, Carragher NO,Ljosa V, Caie PD, Ter Horst R, Sokolnicki KL, Jenkins EL, Daya S, Roberts ME, Jones TR, Singh S, Genovesio A, Clemons PA, Carragher NO, Carpenter AE,Singh S, Bray MA, Jones TR, Carpenter AE,Pawlowski N, Caicedo JC, Singh S, Carpenter AE, Storkey A,Ando DM, McLean C, Berndl M,Caicedo JC, Cooper S, Heigwer F, Warchal S, Qiu P, Molnar C, Vasilevich AS, Barry JD, Bansal HS, Kraus O, Wawer M, Paavolainen L, Herrmann MD, Rohban M, Hung J, Hennig H, Concannon J, Smith I, Clemons PA, Singh S, Rees P, Horvath P, Linington RG, Carpenter AE

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