Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb

Combination therapy of adoptive CTL transfer and anti-CD137 monoclonal antibody. Mice were injected with B16F10/OVA melanoma cells and after 3 or 7 days were treated with OVA-specific CD8+ T cells (Cytotoxic T lymphocytes CTL) plus 1D8 antibody (anti-CD137). 4D timelapse images were taken at either 3 or 6 days after CTL + antibody treatment. Version History August 2017 - added additional phenotype to CMPO ontology mapping

Weigelin B, Bolaños E, Teijeira A, Martinez-Forero I, Labiano S, Azpilikueta A, Morales-Kastresana A, Quetglas JI, Wagena E, Sánchez-Paulete AR, Chen L, Friedl P, Melero I

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