Protein localisation and morphological comparison of normal and cancer cell lines in various media, treated with TNF-alpha or cytoskeleton-modifying small molecules

High Content Analysis was used to quantitatively profile the morphology and NF-kappaB nuclear localization (which serves as a proxy for its activation), in 17 breast cancer and two non_tumor cell lines. Cells were treated with or without TNFa for 1 h or 5 h to capture the first peak and later steady state of NF-kappaB activation. Version History July 2017: screenA - updated some cell line names to be inline with the names used in EFO. MCF7 -> MCF-7, MCF10A -> MCF 10A, JIMT1 -> JIMT-1, MDA-MB-157 -> MDAMB157, MDA-MB-231 -> MDAMB231, MDA-MB-453 -> MDAMB453, SUM149 -> SUM149PT, SUM159 -> SUM159PT, ZR75.1 -> ZR751.

Sero JE, Sailem HZ, Ardy RC, Almuttaqi H, Zhang T, Bakal C

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idr0019-sero-nfkappab/screenA ()

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screenA ( , parquet: -)

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