A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells

We used high-content screening and image analysis to measure effects of 1280 pharmacologically active compounds on complex phenotypes in isogenic cancer cell lines which harbor activating or inactivating mutations in key oncogenic signaling pathways. Using multiparametric chemical-genetic interaction analysis, we measured 300,000 drug-gene-phenotype interactions and observed phenotypic gene-drug interactions for more than 193 compounds, with many affecting phenotypes other than cell growth.

Breinig M, Klein FA, Huber W, Boutros M

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